Humanization of yeast genes
In 2015, we published an article on systematic replacement of essential genes in baker’s yeast with corresponding human orthologs. This work demonstrated that nearly 50% of the essential yeast genes can be replaced by their human counterparts, despite over a billion years of evolutionary divergence between humans and yeast. We discovered that metabolic pathways and protein complexes were either entirely replaceable or not.
My lab at Concordia university will expand on this work to fully humanize genetic systems in yeast.
This article was highlighted at many news and other media outlets, links to which are provided below:
Other news features on this paper: phys.org – Discovery News – The Scientist – Science daily – MeteoWeb (in Italian) – NBC News – Washington Post – Reddit #1 – Science News – Empire State Tribune – Softpedia – Reddit #2 – Daily Mail – redOrbit – Medical Daily – NYC Today – Genetic Literacy Project – Techie News – Tech Times – American Live Wire – Pioneer News – Yahoo News – IFLScience – yeastgenome.org – Ottawa Citizen – PRI